Resource Center

ISHAS Professional & Academic Forum on Targeting Hyaluronan/Hyaluronic Acid (HA) in COVID-19 Infection and Pathology

New Papers

1. COVID-19 infection: the perspectives on immune responses. (2020) Cell Death & Differentiation volume 27, pages1451–1454.

2. Covid-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome. (2020) AJRCCM, in press.

3. SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. (2020) Preprint at bioRxiv.

4. Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue. (2020) Preprint at bioRxiv.

5. Accelerated hyaluronan concentration as the primary driver of morbidity and mortality in high-risk COVID-19 patients: with therapeutic introduction of an oral hyaluronan inhibitor in the prevention of “Induced Hyaluronan Storm” Syndrome. (2020) Preprint at medRxiv.

5. Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin. (2020) Preprint at bioRxiv.

6. Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry. (2020) Preprint at bioRxiv.

7. The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding. (2020) Preprint at bioRxiv.

8. Central nervous system manifestations of COVID-19: A systematic review. (2020) Journal of the Neurological Sciences 413, 16832.

9. Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics. (2020) Preprint at medRxiv.

10. Correlation analysis of the severity and clinical prognosis of 32 cases of patients with COVID-19. (2020) Respiratory Medicine, in press.

11. COVID-19: Transmission, prevention, and potential therapeutic opportunities. (2020) Clin Chim Acta. Sep; 508: 254-266.

12. Molecular Alterations Prompted by SARS-CoV-2 Infection: Induction of Hyaluronan, Glycosaminoglycan and Mucopolysaccharide Metabolism. (2020) Arch Med Res. Jun; S0188-4409(20)30705-0.

13. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. (2020) Cell

14. Hyaluronan is abundant in COVID-19 respiratory secretions. (2020) Preprint at medRxiv.

15. Presence of hyaluronan in lung alveoli in severe Covid-19 – an opening for new treatment options? (2020) JBC

16. IL-13 is a driver of COVID-19 severity. (2021) Preprint at medRxiv.

17. Hymecromone: A Clinical Prescription Hyaluronan Inhibitor for Efficiently Blocking COVID-19 Progression. (2021) Preprint at medRxiv

Relevant Papers

1. Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis. (2019) Matrix Biology 80:14-29.

2. Effects of inhaled high-molecular weight hyaluronan in inflammatory airway disease. (2016) Respir Res. 17(1):123.

3. A pilot clinical trial to determine the safety and efficacy of aerosolized hyaluronan as a treatment for COPD. (2017) Int J Chron Obstruct Pulmon Dis. 12:2747–2752.

4. In-Vivo Efficacy of Recombinant Human Hyaluronidase (rHuPH20) Injection for Accelerated Healing of Murine Retrocalcaneal Bursitis and Tendinopathy. (2020) J Orthop Res. 38(1):59–69.

5. Hyaluronan and Layilin Mediate Loss of Airway Epithelial Barrier Function Induced by Cigarette Smoke by Decreasing E-cadherin. (2012) J. Biol. Chem. 287(50):42288-98.

6. Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation. (2020) J. Biol. Chem. 295, 5278–5291.

7. A Modified Flavonoid Accelerates Oligodendrocyte Maturation and Functional Remyelination. (2020) Glia. 68(2):263-279.