Event Schedule
for the 14th International Conference on Hyaluronan
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Schedule
18:00 Welcome & Start of Meeting
18:15 Rooster Prize: Talks and Award Presentation
19:30 Reception (Rooftop Banquet Room)
7:30 Breakfast
8:30 Keynote Lecture: Paul Kubes (University of Calgary, Canada)
CD44/Hyaluronan as a key adhesion pathway from early life to chronic disease
9:10 Session #1: HA Metabolism and Synthesis (Chairs: Davide Vigetti and Yu Yamaguchi)
9:10 Yu Yamaguchi (Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA)
The structure, catalytic mechanisms, and biology of TMEM2
9:35 Yi Zhu (Baylor College of Medicine, Houston, TX, USA)
HA synthesis and degradation in adipose tissue and liver pathophysiology
10:00 Katja Wegener (Heinrich-Heine-University, Düsseldorf, Germany) Investigating the hyaluronan-rich matrix in bone marrow adipose tissue during development and progression of type 2 diabetes mellitus
10:15 Matej Simek (Contipro, Dolni Dobrouc, Czech Republic)
The role of molecular weight and gut microbiota in the bioavailability of orally-administered hyaluronic acid
10:30 Davide Vigetti (University of Insubria, Varese, Italy)
HAS2-AS1 is a new multi-faceted regulator of triple-negative breast cancer cell metabolism
10:45 Coffee Break
11:25 Session #2: Biophysics and Structural Biology of HA (Chairs: Jennifer Curtis and Jochen Zimmer)
11:25 Jochen Zimmer (University of Virginia School of Medicine, Charlottesville, VA, USA)
Structural and mechanistic insights into hyaluronan synthesis and length control
11:50 Julien Vermot (Imperial College London, UK)
Osmotic forces and hyaluronic acid function in the regulation of cell shape during cardiac morphogenesis
12:15 Adam R Hall (Wake Forest University School of Medicine, Winston Salem, NC, USA)
High-fidelity affinity purification of hyaluronan from diverse matrices
12:30 Anokhi Shah (University of Manchester, Manchester, UK)
PTX3-mediated crosslinking of HC•HA complexes: New insights from structural and biophysical studies
12:45 Ralf P Richter (University of Leeds, Leeds, UK)
Surface-based quantification of the size, concentration and purity of reducing-end functionalised hyaluronan and other glycosaminoglycans
13:00 Yu Jing (Georgia Institute of Technology, Atlanta, USA)
Dynamic hyaluronan biomimetic glycocalyx: studying glycocalyx-mediated cell behaviors
13:15 Lunch on your own
14:45 Session #3: HA in Inflammation and Immunology (Chairs: Mariah Grandoch and David Jackson)
14:45 Mariah Grandoch (University of Düsseldorf, Düsseldorf, Germany)
Identifying the role of hyaluronan synthase 3 in abdominal aortic aneurysms and dissections
15:10 Hedwich Kuipers (Stanford University, Stanford, CA, USA)
Extracellular matrix control of astrocyte-T cell interactions
15:35 Aeliya Zaidi (Cardiff University, Cardiff, UK)
Receptor-mediated tubular internalisation of hyaluronan (HA) in the renal cortex mediates renal protection during ischaemic pre-conditioning
15:50 Dorothea A Erxleben (Wake Forest School of Medicine, Winston-Salem, USA)
Solid-state nanopore analysis of heavy chain-modified hyaluronan as a translational marker of inflammation
16:05 Shrea Roy (Cardiff University, UK), Hyaluronan (HA)
Dependent regulation of vascular smooth muscle cell phenotype and vascular calcification
16:20 Jeffrey L. Bose (University of Kansas Medical Center, Kansas City, USA)
Hyaluronan synthase deficiency and 4-methylumbelliferone treatment reduce staphylococcus aureus-induced necrotic lesion formation
16:35 Poster Preview #1
16:45 Break
17:30 Poster Session (with wine and cheese)
19:30 Dinner on your own
7:30 Breakfast
8:30 Endre Balazs & Janet Denlinger Award Lecture – 2021 Recipient Aaron Petrey (University of Utah, Salt Lake City, Utah, USA)
TSG-6 hyaluronan matrix remodeling activity dampens the inflammatory response during colitis
9:00 Session #4: New Therapeutics and Biotechnological Applications of HA (Chairs: Nadine Nagy and Helena Azevedo)
9:00 Nadine Nagy (Stanford University School of Medicine, Stanford, CA, USA)
Oral hymecromone treatment decreases hyaluronan in humans
9:25 Helena Azevedo (Queen Mary University of London, UK)
Creating complex surpramolecular biomaterials with native hyaluronan: A new paradigm in biomaterials engineering
9:50 Hiroyuki Yoshida (Kao Corporation, Odawara, Japan)
Anti-aging efficacy of 1-ethyl-β-N-acetylglucosaminide, a newly developed inducer of epidermal hyaluronan production
10:05 Andrew Pitsillides (Royal Veterinary College, London, UK)
Hylin, a selective hyaluronan synthesis and export inhibitor protects against spontaneous murine osteoarthritis
10:20 Katherine E Powell (Georgia Institute of Technology, Atlanta, USA)
Enzyme-derived hyaluronan polymer brushes: A new strategy for anti-microbial interfaces
10:35 Coffee Break
11:25 Session #5: HA in Tissue Engineering and Regenerative Medicine (Chairs: Jane Grande-Allen and Sundeep Keswani)
11:25 Sundeep Keswani (Texas Children’s Hospital, Houston, TX, USA)
Roles of hyaluronan in dermal wound healing
11:50 Stephanie Seidlits (University of Texas, Austin, USA)
Hyaluronic Acid-CD44 Signaling Affects Glioblastoma Metabolism, Proliferation, and Invasion
12:15 Claire A Bridges (University of New South Wales, Sydney, Australia)
Evaluating hyperglycaemia induced degradation of the endothelial glycocalyx and resultant changes to endothelial cell-biomatieral interactions towards therapeutic applications
12:30 Chiara Schiraldi (University of Campania "Luigi Vanvitelli", Naples, Italy)
Biotechnological chondroitin alone and combined with hyaluronan as a new promising platform for tissue regeneration
12:45 Thorsten Kirsch (NYU Grossman School of Medicine, New York, USA)
The role of a RHAMM-mimetic peptide (p15-1) in cartilage repair
13:00 Poster Preview #2
13:15 Lunch and Free Time
17:30 Poster Session (with wine and cheese)
19:30 Dinner on your own
7:30 Breakfast
8:30 Keynote Lecture: Jonathan P. Sleeman (University of Heidelberg, Germany)
Hyaluronan: Size Matters!
9:10 Session #6: HA in Neurobiology (Chairs: Hedwich Kuipers and Stephen Back)
9:10 Shinji Miyata (Tokyo University of Agriculture and Technoloigy, Japan)
Structural and functional remodeling of hyaluronan-based extracellular matrix during brain development and maturation
9:35 Justin Dean (University of Auckland, Auckland, New Zealand)
Endogenous neuronal hyaluronan metabolism regulates growth cone dynamics and axonal outgrowth during early neurite development
10:00 Taasin Srivastav (Oregon Health and Science University, Portland, USA)
A role for hyaluronan matrix remodeling in regulating astrocytes during brain development and injury
10:15 Anthony Day (University of Manchester, Manchester, UK)
Localisation and binding properties of inter-alpha-inhibitor heavy chain 3 (hc3) in age-related macular degeneration
10:30 Alec Peters (Oregon National Primate Research Center, Beaverton, OR, USA)
The hyaluronidase cell migration inducing and hyaluronan binding protein is elevated in inflammatory demyelination and inhibits myelin formation
10:45 Coffee Break
11:25 Session #7: HA in Viral Biology (Chairs: Stavros Garantziotis and Paraskevi Heldin)
11:25 Stavros Garantziotis (National Institute of Environmental Health Sciences, Durham, NC, USA)
High molecular weight hyaluronan for prophylaxis and treatment of viral pneumonia
11:50 Stephen Reeves (University of Washington, Seattle, WA, USA)
Determining the role of hyaluronan and it’s modifications during respiratory syncytial virus induced lung disease
12:15 Anna Marchetti (Fidia Farmaceutici Spa, Abano Terme, Italy)
Aerosolized administration of sulfated hyaluronan derivatives to treat SARS-COV-2 infection
12:30 Paul L Bollyky (Stanford University, Stanford, USA)
Hyaluronan is abundant in respiratory secretions from patients with acute and post-acute SARS-COV-2 infection
12:45 Fengying Tang (University of Washington at South Lake Union, Seattle, USA)
The role of the HC-HA matrix in influenza-induced lung inflammation
13:00 Rebecca Dodd (University of Manchester, Manchester, UK)
IL-13 as a modulator of the hyaluronan extracellular matrix in lung
13:15 Lunch on your own
14:50 Session #8: HA in Cancer Biology (Chairs: Sergei Kusmartsev and Melanie Simpson)
14:50 Sergei Kusmartsev (University of Florida, USA)
Contribution of Hyal2-expressing myeloid cells in cancer progression
15:15 Kirsi Rilla (University of Eastern Finland, Kuopio, Finland)
Multiple roles of hyaluronan in extracellular vesicle biology
15: 40 Paraskevi Heldin (Uppsala University, Uppsala, Sweden)
Targeting hyaluronan-CD44 signaling in cancer
15:55 Brenna M Zimmer (NC State University, Raleigh, USA)
UGDH is a regulatory node in UDP-glucuronate priority use
16:10 Alice Browne (National Institutes of Health, Bethesda, USA)
Investigating ECM remodelling in tumorigenesis: Hyaluronidase-expressing genetically engineered mesenchymal stromal cells remodel the hyaluronan-rich tumor extracellular matrix

16:25 Coffee Break
16:45 ISHAS Business Meeting/Informal Poster Viewing
18:00 Walk to Docks
18:30 Boarding
19:00 Conference Dinner Cruise
7:30 Breakfast
8:30 Session #9: HA in Signaling and Cellular Biology (Chairs: Soma Meran and Taasin Srivastava)
8:30 Soma Meran (Cardiff University, UK)
Can we modify the matrix to promote renal recovery following injury?
8:55 Harry Karmouty Quintana (UT Health McGovern Medical School, Houston, TX, USA)
Hyaluronan synthesis, accumulation and pathological consequences in Chronic Lung Diseases
9:20 Vincent C Hascall (Cleveland Clinic, Cleveland, USA)
Surface interaction of heparin with calreticulin on early G0/G1 dividing rat mesangial cells regulates hyperglycemic glucose induced responses
9:35 Tarsis G Ferreira (University of Houston, Houston, USA)
Hyaluronan features a distinct population of transient amplifying cells with progenitor-like characteristics in the corneal epithelium
9:50 Yingcui Li (University of Hartford, West Hartford, USA)
A study of the effects of genetic loss of hyaluronan using computer controlled image analysis of mouse tibial growth plate
10:05 Rashmin C Savani (University of Florida, Gainesville, USA)
RHAMM in the pathogenesis of viral illnesses: Insights and novel therapeutic approaches
10:20 Coffee Break
10:45 Session #10: HA in Development and Aging (Chairs: Edward Harris and Barbara Triggs-Raine)
10:45 Edward Harris (University of Nebraska, NE, USA)
Systemic LPS is cleared by the stabilin/HARE receptors in liver sinusoidal endothelium
11:10 Kaylee Schwertfeger (University of Minnesota, Minneapolis, MN, USA)
Regulation of hyaluronan homeostasis by tissue resident macrophages in the mammary gland
11:35 Francesca E. Duncan (Northwestern University, Chicago, IL, USA)
Cumulus cell expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan
11:50 Michele T. Pritchard (University of Kansas Medical Center, Kansas City, USA)
Dual Hyaluronan Synthase 1 and Haluronan Synthase 3 deficiency protects from age-associated weight gain
12:05 Wendena S Parkes (University of Kansas Medical Center, Kansas City, USA)
Hyaluronan Synthase 3 deficiency does not accelerate reproductive aging
12:20 Short break
12:30 Endre Balazs & Janet Denlinger Award Lecture – 2023 Recipient
13:00 Prize Giving
13:10 Closing Remarks & End of Meeting