Schedule

18:00   Welcome & Start of Meeting

18:15   Rooster Prize: Talks and Award Presentation

19:30   Reception (Rooftop Banquet Room)

7:30     Breakfast

8:30     Keynote Lecture: Paul Kubes (University of Calgary, Canada)

CD44/Hyaluronan as a key adhesion pathway from early life to chronic disease

9:10     Session #1: HA Metabolism and Synthesis (Chairs: Davide Vigetti and Yu Yamaguchi)

9:10     Yu Yamaguchi (Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA)
The structure, catalytic mechanisms, and biology of TMEM2

9:35     Yi Zhu (Baylor College of Medicine, Houston, TX, USA)
HA synthesis and degradation in adipose tissue and liver pathophysiology

10:00   Katja Wegener (Heinrich-Heine-University, Düsseldorf, Germany) Investigating the hyaluronan-rich matrix in bone marrow adipose tissue during development and progression of type 2 diabetes mellitus

10:15   Matej Simek (Contipro, Dolni Dobrouc, Czech Republic)
The role of molecular weight and gut microbiota in the bioavailability of orally-administered hyaluronic acid

10:30   Davide Vigetti (University of Insubria, Varese, Italy)
HAS2-AS1 is a new multi-faceted regulator of triple-negative breast cancer cell metabolism

10:45   Coffee Break

11:25   Session #2: Biophysics and Structural Biology of HA (Chairs: Jennifer Curtis and Jochen Zimmer)

11:25   Jochen Zimmer (University of Virginia School of Medicine, Charlottesville, VA, USA)
Structural and mechanistic insights into hyaluronan synthesis and length control

11:50   Julien Vermot (Imperial College London, UK)
Osmotic forces and hyaluronic acid function in the regulation of cell shape during cardiac morphogenesis

12:15   Adam R Hall (Wake Forest University School of Medicine, Winston Salem, NC, USA)
High-fidelity affinity purification of hyaluronan from diverse matrices

12:30   Anokhi Shah (University of Manchester, Manchester, UK)
PTX3-mediated crosslinking of HC•HA complexes: New insights from structural and biophysical studies

12:45   Ralf P Richter (University of Leeds, Leeds, UK)
Surface-based quantification of the size, concentration and purity of reducing-end functionalised hyaluronan and other glycosaminoglycans

13:00   Yu Jing (Georgia Institute of Technology, Atlanta, USA)
Dynamic hyaluronan biomimetic glycocalyx: studying glycocalyx-mediated cell behaviors

13:15   Lunch on your own

14:45   Session #3: HA in Inflammation and Immunology (Chairs: Mariah Grandoch and David Jackson)

14:45   Mariah Grandoch (University of Düsseldorf, Düsseldorf, Germany)
Identifying the role of hyaluronan synthase 3 in abdominal aortic aneurysms and dissections

15:10   Hedwich Kuipers (Stanford University, Stanford, CA, USA)
Extracellular matrix control of astrocyte-T cell interactions

15:35   Aeliya Zaidi (Cardiff University, Cardiff, UK)
Receptor-mediated tubular internalisation of hyaluronan (HA) in the renal cortex mediates renal protection during ischaemic pre-conditioning

15:50   Dorothea A Erxleben (Wake Forest School of Medicine, Winston-Salem, USA)
Solid-state nanopore analysis of heavy chain-modified hyaluronan as a translational marker of inflammation

16:05   Shrea Roy (Cardiff University, UK), Hyaluronan (HA)
Dependent regulation of vascular smooth muscle cell phenotype and vascular calcification

16:20   Jeffrey L. Bose (University of Kansas Medical Center, Kansas City, USA)
Hyaluronan synthase deficiency and 4-methylumbelliferone treatment reduce staphylococcus aureus-induced necrotic lesion formation

16:35   Poster Preview #1

16:45   Break

17:30   Poster Session (with wine and cheese)

19:30   Dinner on your own

7:30     Breakfast

8:30     Endre Balazs & Janet Denlinger Award Lecture – 2021 Recipient Aaron Petrey (University of Utah, Salt Lake City, Utah, USA)

TSG-6 hyaluronan matrix remodeling activity dampens the inflammatory response during colitis

9:00     Session #4: New Therapeutics and Biotechnological Applications of HA (Chairs: Nadine Nagy and Helena Azevedo)

9:00     Nadine Nagy (Stanford University School of Medicine, Stanford, CA, USA)

Oral hymecromone treatment decreases hyaluronan in humans

9:25     Helena Azevedo (Queen Mary University of London, UK)
Creating complex surpramolecular biomaterials with native hyaluronan: A new paradigm in biomaterials engineering

9:50     Hiroyuki Yoshida (Kao Corporation, Odawara, Japan)
Anti-aging efficacy of 1-ethyl-β-N-acetylglucosaminide, a newly developed inducer of epidermal hyaluronan production

10:05   Andrew Pitsillides (Royal Veterinary College, London, UK)
Hylin, a selective hyaluronan synthesis and export inhibitor protects against spontaneous murine osteoarthritis

10:20   Katherine E Powell (Georgia Institute of Technology, Atlanta, USA)
Enzyme-derived hyaluronan polymer brushes: A new strategy for anti-microbial interfaces

10:35   Coffee Break

11:25   Session #5: HA in Tissue Engineering and Regenerative Medicine (Chairs: Jane Grande-Allen and Sundeep Keswani)

11:25   Sundeep Keswani (Texas Children’s Hospital, Houston, TX, USA)
Roles of hyaluronan in dermal wound healing

11:50   Stephanie Seidlits (University of Texas, Austin, USA)
Hyaluronic Acid-CD44 Signaling Affects Glioblastoma Metabolism, Proliferation, and Invasion

12:15   Claire A Bridges (University of New South Wales, Sydney, Australia)
Evaluating hyperglycaemia induced degradation of the endothelial glycocalyx and resultant changes to endothelial cell-biomatieral interactions towards therapeutic applications

12:30   Chiara Schiraldi (University of Campania "Luigi Vanvitelli", Naples, Italy)
Biotechnological chondroitin alone and combined with hyaluronan as a new promising platform for tissue regeneration

12:45   Thorsten Kirsch (NYU Grossman School of Medicine, New York, USA)
The role of a RHAMM-mimetic peptide (p15-1) in cartilage repair

13:00   Poster Preview #2

13:15   Lunch and Free Time

17:30   Poster Session (with wine and cheese)

19:30   Dinner on your own

7:30     Breakfast

8:30     Keynote Lecture: Jonathan P. Sleeman (University of Heidelberg, Germany)
Hyaluronan: Size Matters!

9:10     Session #6: HA in Neurobiology (Chairs: Hedwich Kuipers and Stephen Back)

9:10     Shinji Miyata (Tokyo University of Agriculture and Technoloigy, Japan)
Structural and functional remodeling of hyaluronan-based extracellular matrix during brain development and maturation

9:35     Justin Dean (University of Auckland, Auckland, New Zealand)
Endogenous neuronal hyaluronan metabolism regulates growth cone dynamics and axonal outgrowth during early neurite development

10:00   Taasin Srivastav (Oregon Health and Science University, Portland, USA)
A role for hyaluronan matrix remodeling in regulating astrocytes during brain development and injury

10:15   Anthony Day (University of Manchester, Manchester, UK)
Localisation and binding properties of inter-alpha-inhibitor heavy chain 3 (hc3) in age-related macular degeneration

10:30   Alec Peters (Oregon National Primate Research Center, Beaverton, OR, USA)
The hyaluronidase cell migration inducing and hyaluronan binding protein is elevated in inflammatory demyelination and inhibits myelin formation

10:45   Coffee Break

11:25   Session #7: HA in Viral Biology (Chairs: Stavros Garantziotis and Paraskevi Heldin)

11:25   Stavros Garantziotis (National Institute of Environmental Health Sciences, Durham, NC, USA)
High molecular weight hyaluronan for prophylaxis and treatment of viral pneumonia

11:50   Stephen Reeves (University of Washington, Seattle, WA, USA)
Determining the role of hyaluronan and it’s modifications during respiratory syncytial virus induced lung disease

12:15   Anna Marchetti (Fidia Farmaceutici Spa, Abano Terme, Italy)
Aerosolized administration of sulfated hyaluronan derivatives to treat SARS-COV-2 infection

12:30   Paul L Bollyky (Stanford University, Stanford, USA)
Hyaluronan is abundant in respiratory secretions from patients with acute and post-acute SARS-COV-2 infection

12:45   Fengying Tang (University of Washington at South Lake Union, Seattle, USA)
The role of the HC-HA matrix in influenza-induced lung inflammation

13:00   Rebecca Dodd (University of Manchester, Manchester, UK)
IL-13 as a modulator of the hyaluronan extracellular matrix in lung

13:15   Lunch on your own

14:50   Session #8: HA in Cancer Biology (Chairs: Sergei Kusmartsev and Melanie Simpson)

14:50   Sergei Kusmartsev (University of Florida, USA)
Contribution of Hyal2-expressing myeloid cells in cancer progression

15:15   Kirsi Rilla (University of Eastern Finland, Kuopio, Finland)
Multiple roles of hyaluronan in extracellular vesicle biology

15: 40  Paraskevi Heldin (Uppsala University, Uppsala, Sweden)
Targeting hyaluronan-CD44 signaling in cancer

15:55   Brenna M Zimmer (NC State University, Raleigh, USA)
UGDH is a regulatory node in UDP-glucuronate priority use

16:10   Alice Browne (National Institutes of Health, Bethesda, USA)
Investigating ECM remodelling in tumorigenesis: Hyaluronidase-expressing genetically engineered mesenchymal stromal cells remodel the hyaluronan-rich tumor extracellular matrix

16:25   Coffee Break

16:45   ISHAS Business Meeting/Informal Poster Viewing

18:00   Walk to Docks

18:30   Boarding

19:00   Conference Dinner Cruise

7:30     Breakfast

8:30     Session #9: HA in Signaling and Cellular Biology (Chairs: Soma Meran and Taasin Srivastava)

8:30     Soma Meran (Cardiff University, UK)
Can we modify the matrix to promote renal recovery following injury?

8:55     Harry Karmouty Quintana (UT Health McGovern Medical School, Houston, TX, USA)
Hyaluronan synthesis, accumulation and pathological consequences in Chronic Lung Diseases

9:20     Vincent C Hascall (Cleveland Clinic, Cleveland, USA)
Surface interaction of heparin with calreticulin on early G0/G1 dividing rat mesangial cells regulates hyperglycemic glucose induced responses

9:35     Tarsis G Ferreira (University of Houston, Houston, USA)
Hyaluronan features a distinct population of transient amplifying cells with progenitor-like characteristics in the corneal epithelium

9:50     Yingcui Li (University of Hartford, West Hartford, USA)
A study of the effects of genetic loss of hyaluronan using computer controlled image analysis of mouse tibial growth plate

10:05   Rashmin C Savani (University of Florida, Gainesville, USA)
RHAMM in the pathogenesis of viral illnesses: Insights and novel therapeutic approaches

10:20   Coffee Break

10:45   Session #10: HA in Development and Aging (Chairs: Edward Harris and Barbara Triggs-Raine)

10:45   Edward Harris (University of Nebraska, NE, USA)
Systemic LPS is cleared by the stabilin/HARE receptors in liver sinusoidal endothelium

11:10   Kaylee Schwertfeger (University of Minnesota, Minneapolis, MN, USA)
Regulation of hyaluronan homeostasis by tissue resident macrophages in the mammary gland

11:35   Francesca E. Duncan (Northwestern University, Chicago, IL, USA)
Cumulus cell expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan

11:50   Michele T. Pritchard (University of Kansas Medical Center, Kansas City, USA)
Dual Hyaluronan Synthase 1 and Haluronan Synthase 3 deficiency protects from age-associated weight gain

12:05   Wendena S Parkes (University of Kansas Medical Center, Kansas City, USA)
Hyaluronan Synthase 3 deficiency does not accelerate reproductive aging

12:20   Short break

12:30   Endre Balazs & Janet Denlinger Award Lecture – 2023 Recipient

13:00   Prize Giving

13:10   Closing Remarks & End of Meeting