Grant Funding

Additional grant funding was provided by the Frost Family Fund, Halozyme, and the Matrix Biology Institute to support the organization and running of the Hyaluronan 2021 meeting. We are very grateful for these and other anonymous donations.

MONDAY, 14 June

(Sessions start at 8:00 AM Pacific Standard Time each day)

8:00     Larry Sherman and Paul Bollyky

Welcome to the meeting

8:05     Tony Day – ISHAS President

Opening of the Conference

Introduction to the Rooster Prize

8:10     Carol de la Motte

Tribute to Vince Hascall

8:20     Vince Hascall

Rooster Prize Talk

8:50     Q&A

8:55     Tony Day

Presentation of Rooster Prize

           

9:00     Break

9:15     Ralf Richter

            Introduction to the Keynote Presentation

9:20     Gijsje Koenderink

            Keynote talk

BIOPHYSICS OF HYALURONAN ACROSS SCALES

10:05   Q&A

10:10   Break

10:40   Session I – HA Metabolism and Synthesis

Chair and Moderator: Soma Meran

            Invited Speaker: Alberto Passi

            THE HARD WORK OF CONTROLLING HYALURONAN SYNTHESIS

11:00   Q&A

11:05   Mariángeles Díaz

4-METHYLUMBELLIFERONE INDUCES ANTI-TUMOR EFFECTS INDEPENDENTLY OF ITS ROLE AS A HYALURONAN SYNTHESIS INHIBITOR ON HUMAN ACUTE MYELOID LEUKEMIA CELLS

11:15   Q&A

11:20   Fumitoshi Irie

            TMEM2 BINDS INTEGRINS AND REGULATES TUMOR CELL ADHESION AND MIGRATION VIA DEGRADATION OF HYALURONAN AT FOCAL ADHESION SITES

11:30   Q&A

11:35   Brenna Zimmer

            UGDH IS A NOVEL SENSORY NODE IN PROSTATE ANDROGEN RESPONSE

11:45   Q&A

11:50   Break

12:00   Session II – HA in Signaling and Cell Biology

Chair and Moderator: Eva Turley

            Invited Speaker: Raphaël Rodriguez

            CD44 MEDIATES METAL UPTAKE AND REGULATES CANCER PROGRESSION

12:20   Q&A

12:25   Michele Pritchard

            HYALURONAN SYNTHESIS INHIBITION NORMALIZES ETHANOL-ENHANCED HEPATIC STELLATE CELL ACTIVATION

12:35   Q&A

12:40   Alec Peters

            CELL MIGRATION INDUCING AND HYALURONAN BINDING PROTEIN (CEMIP) IS DYSREGULATED IN DEMYELINATING DISEASE AND REGULATES OLIGODENDROCYTE PROGENITOR CELL DIFFERENTIATION

12:50   Q&A

12:55   Rashmin C. Savani

            RHAMM AND HYALURONAN ARE CRITICAL TO THE TOLL-LIKE RECEPTOR 7- AND SARS- CoV-2-MEDIATED CYTOKINE STORM AND INFLAMMATION

1:05     Q&A

1:10     Break

1:25     Poster Q&A Concurrent Sessions 1 and 2

Poster Session 1: HA SYNTHESIS AND METABOLISM

Chair and Moderator: Stavros Garantziotis

1:25 Anja Schmaus - HIGHLY SULFATED HYALURONIC ACID POTENTLY INHIBITS CEMIP HYALURONIDASE ACTIVITY, AND REGULATES THE HA METABOLISM, PROLIFERATION AND DIFFERENTIATION OF FIBROBLASTS

1:30 Aimin Wang - NEW PERSPECTIVES: THE ROLES OF HEXOSAMINE BIOSYNTHETIC PATHWAY IN DIABETIC COMPLICATIONS AND THERAPIES

1:35 Rebekka Schneckmann - ENDOTHELIAL HYALURONAN SYNTHASE 3 AUGMENTS POST-ISCHEMIC ARTERIOGENESIS THROUGH CD44/ENOS SIGNALING

1:40 Irina Grigorieva - THE ROLE OF THE HYALURONAN SYNTHASE 2-ANTISENSE (HAS2-AS1) LNC-RNA IN REGULATION OF HA-MEDIATED FIBROTIC CELLULAR RESPONSES

1:45 Irina Grigorieva - ISCHAEMIC PRE-CONDITIONING (IPC) DRIVES EXPANSION OF A PROTECTIVE HAS1 POSITIVE CELL POPULATION IN THE RENAL STROMA, TUBULES AND VASCULATURE

1:50 Tom Wippold - COMPLETE DEPLETION OF HYALURONAN SYNTHASE ACTIVITY IN MURINE SKIN LEADS TO DELAYED WOUND HEALING

1:55 Sarah Buckby - HYALURONIDASE-2 AS A REGULATOR OF DNA

2:00 Jennifer McCracken - RECAPITULATING POST-MENOPAUSAL VAGINAL ENVIRONMENT IN A MURINE MODEL AFTER BILATERAL OOPHERECTOMY

2:05 Ina Sevic - HYALURONAN METABOLISM IS ASSOCIATED WITH DNA REPAIR GENES IN BREAST AND COLORECTAL CANCER

2:10 Laia Saltor Núñe - DERIVATIZATION OF HYALURONAN FOR MUCIN-LIKE STRUCTURES IN GLYCOCALYX MODELS

2:15 Bernard van den Berg - HYPER GLYCOLYSIS REDUCES ENDOTHELIAL HYALURONAN SYNTHESIS IN TUMOR VESSELS

2:20 Wendena S. Parkes - HYALURONAN AND COLLAGEN ARE PROMINENT EXTRACELLULAR MATRIX COMPONENTS IN BOVINE AND PORCINE OVARIES

2:25 Hitoshi Kurihara - METABOLISM AND SKIN IMPROVING EFFECTS OF ORALLY INGESTED HYALURONAN

2:30 Daiana Vitale - COMBINATION OF TREATMENT WITH HYALURONAN PLUS DOXORUBICIN ON HEMATOPOIETIC AND SOLID TUMOR CELLS AFFECTS ENDOTHELIAL CELL BEHAVIOR INDEPENDENTLY OF VEGF EXPRESSION

2:35 Elnur Babayev - CUMULUS CELL EXPANSION AND THE HYALURONIC ACID MATRIX DO NOT CHANGE WITH ADVANCED REPRODUCTIVE AGE

2:40 Molly I Abraham - GENETIC KNOCKDOWN OF HYALURONAN SYNTHASE ENZYMES ALTERS PROCESS OUTGOWTH OF DEVELOPING HIPPOCAMPAL NEURONS IN VITRO

Poster Session 2: HA IN SIGNALING AND CELL BIOLOGY

Chair and Moderator: Nadine Nagy

1:25 Michael P. Lockhart-Cairns - TOWARDS A STRUCTURE OF PTX-3: INSIGHTS INTO ITS INTERACTIONS WITH IαI HEAVY CHAINS THAT MEDIATE HA CROSSLINKING

1:30 Dorothea Erxleben - SELECTIVE ISOLATION OF HEAVY CHAIN-MODIFIED HYALURONAN FOR MOLECULAR ANALYSIS

1:35 Yan Wang - INCREASED MYOFIBROBLAST DIFFERENTIATION IN HYALURONAN SYNTHASE-1/3 NULL MICE IS MEDIATED BY ENHANCED SRF/MRTF FUNCTION DRIVEN BY AN MMP/TGFβR/P38MAPK SIGNALING PATHWAY

1:40 Yu Jing - DIRECT EVIDENCE OF HYALURONAN EXPRESSED AT THE CELL-SUBSTRATUM EXERTS FORCES THAT MODIFY CELL ADHESION

1:45 Richard Scharff - METAL ION DEPENDENT SELF-ASSOCIATION OF PRE-ALPHA-INHIBITOR HEAVY CHAIN 3 (ITIH3)

1:50 Britney Messam - THE RECEPTOR FOR HYALURONAN-MEDIATED MOTILITY AS A REGULATOR OF DRUG SENSITIVITY IN TRIPLE-NEGATIVE BREAST CANCER

1:55 Suniti Misra - A POSITIVE FEEDBACK LOOP BETWEEN β-CATENIN/MDR1 SIGNALING AND CD44V6 SPLICING SUSTAINS CHEMORESISTANCE OF CANCER INITIATING CELLS IN COLORECTAL CANCER

2:00 Yu-Hsuan Huang - CHONDROITIN SULFATE NEGATIVELY REGULATES HYALURONAN BINDING AND MELANOMA METASTASIS TO THE LUNG

2:05 Daniela Poodts - CD44 AND RHAMM AS KEY PLAYERS IN HA-MEDIATED GLIOBLASTOMA MIGRATION

2:10 Constantinos Kolliopoulos - TRAF4/6 IS NEEDED FOR CD44 CLEAVAGE AND MIGRATION VIA RAC1 ACTIVATION

2:15 Lydia-Nefeli Thrapsanioti - LOW MOLECULAR WEIGHT HYALURONAN STIMULATES RHAMM/β-CATENIN COMPLEX FORMATION, β-CATENIN NUCLEAR TRANSLOCATION AND DOWNSTREAM SIGNALING IN HT1080 CELLS

2:20 Martin Šindelář - BIOINFORMATIC ANALYSIS OF TALAROMYCES HYALURONIDASES WITHIN GLYCOSIDE HYDROLASE SUBFAMILY GH16

2:25 Katerina Dostalova - THE EFFECT OF EXOGENOUS HYALURONAN ON MYOFIBROBLAST DIFFERENTIATION IN THE IN VITRO MODEL OF PERITONEAL MEMBRANE

2:30 Irina Grigorieva - THE TRANSCRIPTION FACTOR GATA3 IS AN IMPORTANT REGULATOR OF HA-MEDIATED RESPONSES IN KIDNEY FIBROSIS PROGRESSION VERSUS FIBROSIS RESOLUTION

End of Day 1

Tuesday, 15 June

(Sessions start at 8:00 AM Pacific Standard Time each day)

8:00     Panel Discussion for Trainees

            Moderator: Larry Sherman

            Panelists: Glenn Prestwich, Soma Meran, Melanie Simpson

8:30     Session III – HA in Stem Cells, Development, and Aging

Chair and Moderator: Barbara Triggs-Raine

            Invited Speaker: Andrew Dillin

            THE UNEXPECTED ROLE OF TMEM2 AND HYALURONAN IN ER STRESS AND AGING

8:50     Q&A

8:55     Taasin Srivastava

            HYALURONAN MATRIX REMODELING DURING BRAIN DEVELOPMENT

9:05     Q&A

9:10     Robert B. Vernon

            AUTOCRINE HYALURONAN INFLUENCES SPROUTING AND LUMEN FORMATION DURING HUVEC TUBULOGENESIS IN VITRO

9:20     Q&A

9:25     Break

9:45     Session IV – HA in Disease

Moderator: Melanie Simpson

            Invited Speaker: David Lyden

            TUMOR-DERIVED CEMIP PROMOTES BRAIN METASTASIS

10:05   Q&A

10:10   Invited Speakers: Alexandra Donlan and Tara Sutherland

            IL-13 IS THE DRIVER OF HA BIOSYNTHESIS UNDERPINNING SEVERITY OF COVID-19

10:30   Q&A

10:35   Nadine Nagy

            HYALURONAN PROMOTES DISEASE PROGRESSION IN PRIMARY SCLEROSING CHOLANGITIS

10:45   Q&A

10:50   Aaron C. Petrey

            GLYCOCALYX DEGRADATION IN COVID-19 RELEASES HYALURONAN FRAGMENTS WHICH CAN DIRECTLY INDUCE ENDOTHELIAL BARRIER DYSFUNCTION

11:00   Q&A

11:05   Michael J. Kratochvil

            HYALURONAN CONTRIBUTES TO THE BIOCHEMICAL AND BIOPHYSICAL PROPERTIES OF RESPIRATORY SECRETIONS IN SEVERE SARS-COV-2 (COVID-19) INFECTIONS

11:15   Q&A

11:20   Break

11:50   Session V – Advances in HA Biotechnology

Chair and Moderator: Anna Plaas

            Invited Speaker: Jennifer Curtis

            HYALURONAN FORCES IN CELL ADHESION PROBED WITH TUNABLE GLYCOCALYX

12:10   Q&A

12:15   Theodoros Karalis

             A NOVEL SMALL MOLECULE INHIBITOR OF HYALURONAN SYNTHESIS

12:25   Q&A

12:30   Stavros Garantziotis

            HIGH MOLECULAR WEIGHT HYALURONAN AMELIORATES INFECTION WITH SARS-COV2

12:40   Q&A

12:45   Diana Egorova

            A RAPID AND HIGH-THROUGHPUT METHOD FOR ANALYZING MOLECULAR WEIGHT OF HYALURONAN IN ANIMAL TISSUE SAMPLES

12:55   Q&A

1:00     Break

1:15     Poster Q&A Concurrent Sessions 3 and 4

Poster Session 3: HA in Stem Cells, Development, Aging, and Disease

Chair and Moderator: Stavros Garantziotis

1:15 Corinne Demler - DIFFERENTIAL HYALURONAN REGULATION IS CRITICAL FOR LEFT/RIGHT ASYMMETRY IN INTESTINAL DEVELOPMENT

1:20 Shlomi Cohen - HYALRONAN REGULATES NEURAL CREST MIGRATION

1:25 Rashi Karunasinghe - THE HYALURONAN CORNERSTONE: AN EXTRACELLULAR MATRIX MOLECULE THAT REGULATES EARLY NEURITE OUTGROWTH IN HIPPOCAMPAL NEURONS

1:30 Giulia Giubertoni – INTERACTIONS BETWEEN CATIONS AND HYALURONAN: A QUESTION OF SIZE OR CHARGE?

1:35 Hector Martinez-Seara -N-GLYCOSYLATION BLOCKS AND SIMULTANEOUSLY FOSTERS DIFFERENT RECEPTOR-LIGAND BINDING SITES: THE CHAMELEONIC CD44-HYALURONAN INTERACTION

1:40 Farners Amargant – HYALURONAN SYNTHESIS IS REQUIRED FOR PREANTRAL FOLLICLE GROWTH IN THE MOUSE

1:45 Pierre Weiss - A SILATED HYALURONIC ACID HYDROGEL PLATFORM WITH BIOINSPIRED PROPERTIES FOR TISSUE ENGINEERING

1:50 Megan Hamilton - A CELL DELIVERY SYSTEM BASED ON DEGRADABLE HYALURONIC ACID MICROBEADS

1:55 Urban Hellman - SARS-CoV-2-INDUCED REGULATION OF HYALURONAN METABOLISM IN AN AIR-LIQUID INTERFACE CELL CULTURE

2:00 Stavros Garantziotis - TRANSLATIONAL APPLICATION OF HIGH MOLECULAR WEIGHT HYALURONAN IN AIRWAY DISEASE

2:05 Stephen R. Reeves - AIRWAY EPITHELIAL CELLS DISPLAY INCREASED ACCUMULATION OF HYALURONAN IN THE EXTRACELLULAR MATRIX AND ENHANCED NEUTROPHIL RETENTION FOLLOWING RESPIRATORY SYNCYTIAL VIRUS INFECTION

2:10 Marco Piroth - HYALURONAN SYNTHASE 3 DEFICIENCY RESULTS IN ADVERSE REMODELING AND DECREASED CARDIAC CD4-T-CELL ABUNDANCE AFTER ACUTE ISCHEMIA

2:15 Meghana Pendyala - HYALURONAN TURNOVER IN SYNOVIOCYTES IS SENSITIVE TO CYCLIC STRAIN MAGNITUDE

2:20 Hunter Martinez – CD44V6 PROMOTES FOXP3 TREG HOMEOSTASIS BUT ITS EXPRESSION IS REDUCED IN T1D

2:25 Shrea Roy - HYALURONAN (HA) DEPENDENT REGULATION OF VASCULAR SMOOTH MUSCLE CELL PHENOTYPE AND VASCULAR CALCIFICATION. (VC) IN CARDIORENAL DISEASE

2:30 May J Reed - VIABLE BRAIN MICROVESSELS FOR THE STUDY OF EXTRACELLULAR MATRIX IN ALZHEIMER’S DISEASE

2:35 Anna Kocurkova - ENDOGENOUS HYALURONAN IS PARTICIPATING IN DEVELOPMENT OF PERITONEAL ADHESIONS

2:40 Sofia Spataro - IDENTIFICATION OF AMINO ACIDS ESSENTIAL FOR CEMIP ACTIVITY TOWARDS EXPLORING ITS ROLE IN ALPORT SYNDROME

Poster Session 4: HA in Disease and Advances in HA Biotechnology

Chair and Moderator: Nadine Nagy

1:15  Vojtěch Pavlík - SKIN CELLS ENHANCE CHOLESTEROL METABOLISM WHEN TREATED WITH RETINOIC OR OLEIC ACID GRAFTED TO HYALURONAN

1:20 Chunyue Wang - HYALURONAN, A SCAFFOLD FOR SUPERSELECTIVE TARGETING OF TUMOUR CELLS

1:25 Mary K. Cowman - HA NETWORKING IN SOLUTION MEDIATED BY TSG-6 CAN BE DISRUPTED BY COMPETITIVE BINDING OF HEPARAN SULFATE

1:30 Arianna Parnigoni - HAS2-AS1 OVEREXPRESSION MEDIATES APOPTOSIS INDUCTION IN MDA-MB-231 TRIPLE NEGATIVE BREAST CANCER CELLS INDEPENDENTLY FROM HYALURONAN METABOLISM

1:35 - Zoe Price - THE ROLE OF MOLECULAR WEIGHT OF HYALURONAN IN OVARIAN CANCER STEM CELL SIGNALLING PATHWAYS AND CHEMORESISTANCE

1:40 Rebecca J Dodd - CHEMICAL MODIFICATION OF HYALURONAN OLIGOSACCHARIDES TO MODULATE INTERACTIONS WITH HYALURONAN-BINDING PROTEINS

1:45 Sumitra Srimasorn - SIZING HA AND OTHER GLYCOSAMINOGLYCANS ON SURFACES

1:50 Miroslava Rysová - PERFORMANCE OF HYALURONAN-NANOFIBRES CONJUGATES IN CATIONIC DRUGS DELIVERY

1:55 Celeste Di Meo - HYALURONAN SIZE AFFECTS BIOPHYSICAL AND BIOCHEMICAL FEATURES AND STABILITY PROPERTIES: CHARACTERIZATION OF A WIDE RANGE OF INCREASING MOLECULAR WEIGHT FAMILIES

2:00 Vassallo Valentina – BIOFERMENTATIVE GLYCOSAMINOGLYCANS BASED GELS MODULATE INFLAMMATION MARKERS IN OSTEOARTHRITIS IN VITRO MODEL BASED ON HUMAN PRIMARY CELLS

2:05 Antonietta Stellavato – DIFFERENT MOLECULAR WEIGHT HYALURONAN BASED GELS MAY AFFECT BONE REGENERATION THROUGH DIFFERENTIATION OF DENTAL PULP STEM CELLS

2:10 Cornelia Zapp - NATURAL PRESENTATION OF GLYCOSAMINOGLYCANS IN TUNABLE CELL-INSTRUCTIVE MICROENVIRONMENTS

2:15 Romana Šínová - USE OF UNLABELED AND LABELED HA IN STUDY OF HA EPIDERMAL PENETRATION

2:20 Chiara Schiraldi - ARE HYALURONIC ACID AND CHONDROITIN BASED GELS PLAYING A ROLE IN COMMITMENT OF MESENCHYMAL STEM CELLS TO CHONDROCYTE PROGENITORS AND IN THE DIFFERENTIATION OF PROGENITORS TO MATURE CHONDROCYTES?

2:25 Denys Biriukov - WHAT IS TRUTH AND NOT IN MOLECULAR DYNAMICS SIMULATIONS OF HYALURONAN–PEPTIDE INTERACTIONS?

2:30 Noriyuki Yuasa - BINDING PROPERTIES AND PROTECTIVE EFFECTS OF SULFATED HYALURONIC ACID ON GROWTH FACTORS

2:35 Sergey Uspenskii – MECHANISM OF THE EFFECT OF BORAX ON THE RHEOLOGICAL PROPERTIES OF SODIUM HYALURONATE SOLUTIONS

2:40 Felipe Rivas - OPTIMIZING THE QUANTITATIVE ANALYSIS OF HYALURONIC ACID WITH A SOLID-STATE NANOPORE PLATFORM

2:50     Tony Day

Presentation of Awards

2:55     Larry Sherman and Paul Bollyky

            End of Meeting

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