ISHAS Professional & Academic Forum on Targeting Hyaluronan/Hyaluronic Acid (HA) in COVID-19 Infection and Pathology. (You do not need to be a Member of ISHAS to post on this forum.)

New paper showing HA is elevated in lungs of COVID-19 patients with severe symptoms

Please see the following paper showing that high levels of HA in the lungs of COVID-19 patients is associated with disease severity: Correlation analysis of the severity and clinical prognosis of 32 cases of patients with COVID-19. (2020) Respirat...
Anthony Day Forum Moderator
New Member

Increased plasma HA and hyaluronidase activity in COVID19

Our laboratory has been fortunate to work with a number of ICU docs from the outset of the pandemic and have a growing repository of samples from COVID-19 patients we have paired with clinical data and a 41-panel inflammatory cytokine array. While we...

COVID19- NIH Resources/Information Website link

A useful website for up-to- date info from NIH re funding, clinical trials etc.
Anna Plaas Forum Moderator
New Member

COV 19 IL6/IL1 Lung inflammation

Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. Conti P, Ronconi G, Caraffa A, Gallenga CE, Ross R, Frydas I, Kritas SK. J Biol Regul Homeost Age...
Anna Plaas Forum Moderator
New Member

New paper on ITIH3 and ITIH4 as biomarkers for COVID-19

A paper has just been published as a preprint showing that ITIH3 and ITIH4 (aka heavy chain 3 and heavy chain 4) are 2 of 27 biomarkers that distinguish mild and severe forms of COVID-19: Clinical classifiers of COVID-19 infection from novel ultra...
Anthony Day Forum Moderator
New Member

New funding announcements from NIAID

Good morning, below are new opportunities from NIAID for a R21 and R01 grant application. PAR-20-177: Emergency Awards: Rapid Investigation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19) (R2...

Use of hyaluronidase as a therapy?

As you will have seen from the Introduction to the Forum one possible way to treat the lung pathologies associated with COVID-19 would be by using hyaluronidase; this of course would need to be carefully assessed and tested. Mike LaBarre (CTO Halo...

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