ISHAS COVID-19/HYALURONAN FORUM

ISHAS Professional & Academic Forum on Targeting Hyaluronan/Hyaluronic Acid (HA) in COVID-19 Infection and Pathology. (You do not need to be a Member of ISHAS to post on this forum.)
  1. Anthony Day
  2. New Papers
  3. Wednesday, 06 May 2020
A paper has just been published as a preprint showing that ITIH3 and ITIH4 (aka heavy chain 3 and heavy chain 4) are 2 of 27 biomarkers that distinguish mild and severe forms of COVID-19:

Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics. (2020) Preprint at medRxiv.
https://doi.org/10.1101/2020.04.27.20081810

Other biomarkers are components of the complement system, which is interesting given that we recently described a new role for the related ITIH1 as a regulator of the alternative pathway of complement:

Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation. (2020) J. Biol. Chem. 295, 5278–5291.
https://doi.org/10.1074/jbc.RA119.011916
Comment
It would be very interesting to know if these markers are also elevated in the COVID-19 infected children who are showing the Kawasaki-like syndrome?
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