A paper has just been published as a preprint showing that ITIH3 and ITIH4 (aka heavy chain 3 and heavy chain 4) are 2 of 27 biomarkers that distinguish mild and severe forms of COVID-19:
Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics. (2020) Preprint at medRxiv.
Other biomarkers are components of the complement system, which is interesting given that we recently described a new role for the related ITIH1 as a regulator of the alternative pathway of complement:
Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation. (2020) J. Biol. Chem. 295, 5278–5291.