ISHAS COVID-19/HYALURONAN FORUM

ISHAS Professional & Academic Forum on Targeting Hyaluronan/Hyaluronic Acid (HA) in COVID-19 Infection and Pathology. (You do not need to be a Member of ISHAS to post on this forum.)
  1. Stavros Garantziotis
  2. Hyaluronan in the Pathogenesis of COVID-19
  3. Thursday, 07 May 2020
Below preprints suggest that heparin, but not chondroitin, binds to the SARS-CoV-2 spike protein. a GAG-binding motif (XBBXBX) is suggested and some modeling presented. This would suggest that interfering with GAG binding may influence virus binding and entry to the cell.

https://www.biorxiv.org/content/10.1101/2020.04.14.041459v1
https://www.biorxiv.org/content/10.1101/2020.02.29.971093v2
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Anthony Day
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Hi Stavros,

Thanks for your post. Both of these publications are already in the list of "relevant papers" - see 12 and 13. They are certainly very interesting studies.

Kind wishes,

Tony
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