ISHAS Professional & Academic Forum on Targeting Hyaluronan/Hyaluronic Acid (HA) in COVID-19 Infection and Pathology. (You do not need to be a Member of ISHAS to post on this forum.)

Workshop on COVID-19/HA research?

Dear Forum Subscribers, Would you be interested in attending a Zoom workshop to hear about ongoing research activities on the role of HA in COVID-19 infection/pathology? If there is sufficient interest then we will endeavor to organise such a m...

New paper showing HA is elevated in lungs of COVID-19 patients with severe symptoms

Please see the following paper showing that high levels of HA in the lungs of COVID-19 patients is associated with disease severity: Correlation analysis of the severity and clinical prognosis of 32 cases of patients with COVID-19. (2020) Respirat...
Anthony Day Forum Moderator
New Member

Are there any biorepositories of specimens or tissues from COVID-19 patients available?

It would be very interesting to assess hyaluronan levels in patients and animal models infected with COVID-19. Based on pre-existing studies, we expect that hyaluronan will be elevated in the lung tissues of patients with ARDS....
Barbara Triggs-Raine Forum Moderator
No Ranking

Increased plasma HA and hyaluronidase activity in COVID19

Our laboratory has been fortunate to work with a number of ICU docs from the outset of the pandemic and have a growing repository of samples from COVID-19 patients we have paired with clinical data and a 41-panel inflammatory cytokine array. While we...

Testing treatments for lung fibrosis

I received this yesterday - a CRO offering an IPF model to test therapeutics on lung fibrosis, which could be relevant as treatments will be needed post COVID-19 infection or due to time spent on ventilators (see Eva Turley's comment in the pdf summa...

COVID19- NIH Resources/Information Website link

A useful website for up-to- date info from NIH re funding, clinical trials etc.
Anna Plaas Forum Moderator
New Member

Publications on Hyase or Chondroitinase treatments for pulmonary fibrosis

Modulation of bleomycin-induced lung fibrosis by pegylated hyaluronidase and dopamine receptor antagonist in mice. Skurikhin EG, Pershina OV, Reztsova AM, Ermakova NN, Khmelevskaya ES, Krupin VA, Stepanova IE, Artamonov AV, Bekarev AA, Madonov PG, D...

Heparin binding to SARS-CoV-2 spike protein

Below preprints suggest that heparin, but not chondroitin, binds to the SARS-CoV-2 spike protein. a GAG-binding motif (XBBXBX) is suggested and some modeling presented. This would suggest that interfering with GAG binding may influence virus binding ...

COV 19 IL6/IL1 Lung inflammation

Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. Conti P, Ronconi G, Caraffa A, Gallenga CE, Ross R, Frydas I, Kritas SK. J Biol Regul Homeost Age...
Anna Plaas Forum Moderator
New Member

New paper on ITIH3 and ITIH4 as biomarkers for COVID-19

A paper has just been published as a preprint showing that ITIH3 and ITIH4 (aka heavy chain 3 and heavy chain 4) are 2 of 27 biomarkers that distinguish mild and severe forms of COVID-19: Clinical classifiers of COVID-19 infection from novel ultra...
Anthony Day Forum Moderator
New Member

New funding announcements from NIAID

Good morning, below are new opportunities from NIAID for a R21 and R01 grant application. PAR-20-177: Emergency Awards: Rapid Investigation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19) (R2...

Use of hyaluronidase as a therapy?

As you will have seen from the Introduction to the Forum one possible way to treat the lung pathologies associated with COVID-19 would be by using hyaluronidase; this of course would need to be carefully assessed and tested. Mike LaBarre (CTO Halo...

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